Author

Lauren A. Laboissonniere

University of FloridaORCID 0000-0002-4260-5900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Andrew BerglundiD· 2 shared Laura P.W. RanumiD· 2 shared Tao ZuiD· 2 shared Alfredo BruscoiD· 1 shared Amrutha Pattamatta· 1 shared Barbara A Perez· 1 shared Christopher Manuel GomeziD· 1 shared Eric T. WangiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

J. Andrew BerglundORCID

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2 papers

Recent·Most cited

GeneticsEMBO Molecular MedicinePeer-reviewedOct 11, 2021

CCG*CGG interruptions in high penetrance SCA8 families increase RAN translation and protein toxicity

Barbara A Perez, Hannah K Shorrock, Mónica Báñez-Coronel…·Laura P.W. Ranum

This study shows that CCG*CGG interruptions in SCA8 repeat expansions increase RAN protein levels and toxicity, contributing to higher disease penetrance.

37 citations

humanstatistical model

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NeuroscienceHuman Molecular GeneticsPeer-reviewedDec 15, 2020

Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice

Amrutha Pattamatta, Lien Nguyen, Hailey R. Olafson…·Laura P.W. Ranum

This study shows longer G4C2 repeats in C9orf72 transgenic mice lead to earlier disease onset, higher penetrance, and more RNA foci, with alternative splicing changes as early biomarkers.

19 citations

mouseexperimental assay

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