Author

Tao Zu

University of FloridaORCID 0000-0002-7606-206XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Laura P.W. RanumiD· 4 shared J. Andrew BerglundiD· 2 shared Lauren A. LaboissonniereiD· 2 shared Mónica Báñez-CoroneliD· 2 shared S. H. Subramony· 2 shared Tetsuo AshizawaiD· 2 shared Alexis B. Tays· 1 shared Alfredo BruscoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Laura P.W. RanumORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Repeat associated non-AUG translation as a common mechanism for the polyGln ataxias

Mónica Báñez-Coronel, Tao Zu, Madeline Aldridge, Shu Guo, Ramadan Ajredini, Deborah Morrison, Alexis B. Tays, Lisa A. Duvick, Olga Pletniková, Anthony T. Yachnis, Juan Carlos Troncoso, Henry Lauris Paulson, Hayley S. McLoughlin, Tetsuo Ashizawa, S. H. Subramony, , Laura P.W. Ranum

The paper identifies sense and antisense RAN proteins as a common mechanism in CAG-SCAs, showing their accumulation and toxicity in brain regions and demonstrating metformin's ability to reduce RAN protein levels.

Cell Reports · Dec 19, 2025Peer-reviewedNeuroscience

Staufen blocks autophagy in neurodegeneration

Sharan Paul, Warunee Dansithong, Mandi Gandelman, Karla Patricia Figueroa, Tao Zu, Laura P.W. Ranum, Daniel R. Scoles, Stefan M. Pulst

The paper investigates how STAU1 interacts with mTOR to hyperactivate it and inhibit autophagy in neurodegenerative disease models.

bioRxiv · Mar 30, 2022 · PreprintNeuroscience

CCG*CGG interruptions in high penetrance SCA8 families increase RAN translation and protein toxicity

Barbara A Perez, Hannah K Shorrock, Mónica Báñez-Coronel, Tao Zu, Lisa E. L. Romano, Lauren A. Laboissonniere, Tammy S. Reid, Yoshio Ikeda, Kaalak Reddy, Christopher Manuel Gomez, Thomas D. Bird, Tetsuo Ashizawa, Lawrence J. Schut, Alfredo Brusco, J. Andrew Berglund, , Laura P.W. Ranum

This study shows that CCG*CGG interruptions in SCA8 repeat expansions increase RAN protein levels and toxicity, contributing to higher disease penetrance.

EMBO Molecular Medicine · Oct 11, 2021Peer-reviewedGenetics

Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice

Amrutha Pattamatta, Lien Nguyen, Hailey R. Olafson, Marina M. Scotti, Lauren A. Laboissonniere, Jared I. Richardson, J. Andrew Berglund, Tao Zu, Eric T. Wang, Laura P.W. Ranum

This study shows longer G4C2 repeats in C9orf72 transgenic mice lead to earlier disease onset, higher penetrance, and more RNA foci, with alternative splicing changes as early biomarkers.

Human Molecular Genetics · Dec 15, 2020Peer-reviewedNeuroscience