Catalytically inactive SHP1-C453S mutant gain of "robust LLPS" function
Qichen Zhang, Tianyue Sun, Qi Chen, Guangya Zhu, Xiangyu Kong, Yiqi Du
The paper shows that the SHP1-C453S mutant, which lacks catalytic activity, has enhanced liquid-liquid phase separation (LLPS) ability, suggesting a link between conformational changes and LLPS.
bioRxiv · Mar 6, 2024 · PreprintMolecular Biology