Author

Tianyue Sun

ORCID 0000-0002-9080-3215Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Approach:experimental assay· 1

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Guangya ZhuiD· 1 shared Qi CheniD· 1 shared Qichen ZhangiD· 1 shared Xiangyu KongiD· 1 shared Yiqi DuiD· 1 shared

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Guangya ZhuORCID

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Molecular BiologybioRxivPreprintMar 6, 2024

Catalytically inactive SHP1-C453S mutant gain of "robust LLPS" function

Qichen Zhang, Tianyue Sun, Qi Chen…·Yiqi Du

The paper shows that the SHP1-C453S mutant, which lacks catalytic activity, has enhanced liquid-liquid phase separation (LLPS) ability, suggesting a link between conformational changes and LLPS.

DOI 10.1101/2024.03.06.583685

experimental assay

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