Xiangyu Kong

This study shows that juxtaposing amnion-like cells with human pluripotent stem cells initiates gastrulation behaviors, including primitive streak formation and mesendodermal differentiation.

The paper shows that the SHP1-C453S mutant, which lacks catalytic activity, has enhanced liquid-liquid phase separation (LLPS) ability, suggesting a link between conformational changes and LLPS.

The paper shows BMP signaling initiates WNT, which initiates NODAL in human gastruloids, revealing dynamic signaling waves that mediate epiblast patterning without a signaling gradient.