Christoph Schramm

A non-catalytic function of a disintegrin and metalloprotease 10 determines hepatic progenitor cell fate

This study shows that ADAM10's non-catalytic function, not its enzymatic activity, regulates hepatic progenitor cell fate and liver regeneration.

Next-generation phenotyping integrated in a national framework for patients with ultra-rare disorders improves genetic diagnostics and yields new molecular findings

The paper evaluates a structured diagnostic framework for ultra-rare diseases, showing improved genetic diagnoses and novel gene-disease associations using exome sequencing and AI tools.

Pathogen Detection in RNA-Seq Data with Pathonoia

Pathonoia detects viruses and bacteria in RNA-seq data with high precision and recall, outperforming existing methods and providing insights into microbe-host interactions.

GOAT: Deep learning-enhanced Generalized Organoid Annotation Tool

GOAT is a deep learning tool for annotating organoids from microscopy images, showing high performance across diverse organoid systems.