Stefan Rose‐John

This study identifies gp130 as a key receptor for a bidirectional neuron-microglia circuit that enhances neuroprotection after CNS injury.

This study shows that a maternal high-fat diet increases neonatal systemic inflammation and predisposes to infant lung disease via neutrophil-mediated IL-6 trans-signaling.

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

This study shows that ADAM10's non-catalytic function, not its enzymatic activity, regulates hepatic progenitor cell fate and liver regeneration.

This study shows ADAM17 on myeloid cells drives hepatic DNA damage repair and tumour formation in HCC, suggesting it as a therapeutic target.

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.