Author

Upasana L. Mallimadugula

Washington University in St. LouisORCID 0000-0002-4269-3541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Gregory R. BowmaniD· 2 shared Maxwell I. ZimmermaniD· 2 shared Andrea SorannoiD· 1 shared Justin J. MilleriD· 1 shared Matthew A. CruziD· 1 shared Melissa D. Stuchell‐BreretoniD· 1 shared Neha VithaniiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

Gregory R. BowmanORCID

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2 papers

Recent·Most cited

Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

Upasana L. Mallimadugula, Matthew A. Cruz, Neha Vithani, Maxwell I. Zimmerman, Gregory R. Bowman

The paper investigates whether a cryptic pocket in VP35 affects dsRNA binding, showing that open and closed conformations bind different RNA features.

eLife · Sep 2, 2025Peer-reviewedBiophysics

Accounting for fast vs slow exchange in single molecule FRET experiments reveals hidden conformational states

Justin J. Miller, Upasana L. Mallimadugula, Maxwell I. Zimmerman, Melissa D. Stuchell‐Brereton, Andrea Soranno, Gregory R. Bowman

This study improves agreement between smFRET experiments and molecular dynamics simulations by accounting for time-averaging, revealing hidden conformational states in proteins.

Journal of Chemical Theory and Computation · Nov 26, 2024Peer-reviewedBiophysics