Justin J. Miller

This study uses molecular dynamics simulations to show that antibody maturation increases rigidity in protein-contacting regions and flexibility at glycan interfaces.

This study evaluates AI and physics-based simulations in predicting cryptic pocket opening probabilities in proteins, finding they can predict mutation effects but not absolute probabilities accurately.

This study identifies FrmB as a serine hydrolase that regulates central carbon metabolism and small colony variant formation in S. aureus.

The paper investigates how YM-254890 specifically inhibits Gq/11 by stabilizing the G-Gβγ complex through allosteric effects, revealing its mechanism as an 'allosteric glue'.

The paper identifies acylpeptide hydrolase (APEH) from red blood cells as an enzyme imported by malaria parasites that activates lipophilic ester prodrugs, offering a new strategy to overcome drug resistance.

This study improves agreement between smFRET experiments and molecular dynamics simulations by accounting for time-averaging, revealing hidden conformational states in proteins.