Andrea Soranno

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

This study shows phosphorylation of SARS-CoV-2 N protein toggles its condensate state between membrane-wetting and engulfment, revealing a regulatory mechanism for viral RNA replication and packaging.

This paper quantifies the dimerization mechanisms of SARS-CoV-2 Nucleocapsid protein, showing it forms a high-affinity dynamic complex with a dissociation constant of ~12 nM.

This study improves agreement between smFRET experiments and molecular dynamics simulations by accounting for time-averaging, revealing hidden conformational states in proteins.

This paper investigates the structural dynamics of the intrinsically disordered troponin-T linker region using single-molecule FRET, molecular dynamics simulations, and functional assays, showing its dynamic behavior and how a mutation affects intermolecular interactions.