T. J. Sego

Modeling Epithelial Morphogenesis and Cell Rearrangement during Zebrafish Epiboly: Tissue Deformation, Cell-Cell Coupling, and the Mechanical Response to Stress

The paper develops an agent-based model of zebrafish epiboly to study force generation and tissue deformation during early development.

Injury-Specific Muscle Regeneration: A Computational Blueprint for Cellular and Cytokine Drivers

The paper extends a computational model of skeletal muscle regeneration to simulate and validate injury-specific responses to CTX, FI, and EC injuries, revealing distinct cytokine and cell dynamics across injury types.

Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of Xenopus mesendoderm

The paper develops a Cellular-Potts model to study how cohesotaxis, tissue geometry, and cell intercalation influence collective migration velocity in Xenopus mesendoderm.

PhenoCellPy: A Python package for biological cell behavior modeling

PhenoCellPy provides a Python package to model cell behaviors and states, enabling integration with other modeling frameworks.

Multicellular Spatial Model of RNA Virus Replication and Interferon Responses Reveals Factors Controlling Plaque Growth Dynamics

The paper develops a spatial multicellular model of RNA virus replication and interferon responses, showing how interferon concentrations and diffusion rates affect plaque growth dynamics.

A Multiscale Multicellular Spatiotemporal Model of Local Influenza Infection and Immune Response

This paper develops a multiscale spatiotemporal model of influenza infection and immune response, showing that localized viral exposure significantly impacts infection severity.