Sophie M. Morgani

This study shows Hox genes maintain periosteal stem cells in an uncommitted state and mediate region-specific reprogramming in adult bone.

The paper quantifies signaling responses in mouse primordial germ cells and their niche, showing distinct BMP and MAPK responses compared to somatic cells, but comparable WNT responses, and finds BMP signaling is not cell-autonomously required for PGC-like differentiation.

This study shows that Rreb1 is essential for mouse embryonic development, regulating epithelial architecture and invasiveness during gastrulation.

The paper develops a mouse pluripotent stem cell micropattern system to study regionalized fate specification and patterning, revealing how signals direct distinct identities and spatial organization.