MSC-delivered High-Affinity Variants of soluble PD1 lead to tumour regression
Serap Gokcen, Tianyuan Chu, P Blair, Natalia Krajewska, Greg Nicholas Brooke, Stuart A. Rushworth, Pierre Philippe Laissue, Ralf Michael Zwacka, Andrea Mohr
This paper develops a cell-based immune checkpoint therapy using MSCs to deliver a high-affinity sPD1 variant, showing anti-tumour activity in a mouse model.
Cytotherapy · Jun 11, 2026Peer-reviewedCancer Biology