Greg Nicholas Brooke

This paper develops a cell-based immune checkpoint therapy using MSCs to deliver a high-affinity sPD1 variant, showing anti-tumour activity in a mouse model.

This study shows that protein-coding gene expression can be reliably estimated from small RNA-seq data, comparable to total RNA-seq, and applies this to breast cancer datasets without total RNA-seq.

The paper develops methods to improve the solubility and stability of intrabodies by optimizing linker design, domain orientation, and charge properties, enabling effective intracellular targeting of cytoplasmic proteins.

This study identifies patient-specific and common nucleosome repositioning patterns in breast cancer tissues and links them to cancer pathways and liquid biopsy applications.

This study shows RSK2 and RSK4 promote prostate cancer proliferation through distinct mechanisms, both dependent and independent of androgen signaling.

The paper develops a modified biosensor to distinguish subcellular accumulation of H2O2 and lipid hydroperoxides in plant cells under stress.

This study shows PSIP1 reduces R-loops at transcription sites, preventing DNA damage and maintaining genome integrity in human and mouse cells.