tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans
Nikoletta Galambos, Olivia J Crocker, Blair K. Schneider, Kennelly S. Allerton, Katrin E. Gross, Alexandra Elisabeth Schneider, Jared Lynch, Onur Yukselen, Alper Küçükural, Colin C. Conine
The paper shows that tRNA-derived RNAs (tDRs) in sperm of C. elegans can transmit epigenetic phenotypes to offspring through RNaseT2-mediated regulation of tDR length.
Nature Communications · Mar 15, 2026Peer-reviewedDevelopmental Biology