Olivia J Crocker

tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans

The paper shows that tRNA-derived RNAs (tDRs) in sperm of C. elegans can transmit epigenetic phenotypes to offspring through RNaseT2-mediated regulation of tDR length.

Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells

This study links in vitro transcription factor affinities to in vivo single-molecule chromatin states using thermodynamic models and experimental data for KLF1.

A human-specific regulatory mechanism revealed in a preimplantation model

The paper investigates the role of HERVK LTR5Hs elements in human preimplantation development, showing their cis-regulatory impact on the epiblast transcriptome and their essential role in blastoid formation through ZNF729 activation.

Long range regulation of transcription scales with genomic distance in a gene specific manner

The paper shows that enhancer-promoter communication scales with genomic distance in a gene-specific manner, independent of 3D contact frequency or chromatin state.