Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer's disease
Yuanyuan Wang, Tiffany Z. Wu, Alvin Gogineni, Ming‐Chi Tsai, Lukasz Jan Kielpinski, Anubha Mahajan, Shristi Pandey, Luis F. Schachner, John C. Tran, Cong Wu, Stephen P. Schauer, Anne Biever, Sidsel Boesen, Meiling Li, Alexander Munk, , Jesse E. Hanson
This study identifies the classical complement pathway as a therapeutic target in Alzheimer's disease and demonstrates the efficacy of antisense oligonucleotides in rescuing synapse loss in mouse models.
bioRxiv · Aug 23, 2024 · PreprintNeuroscience