Author

Tiffany Z. Wu

GenentechORCID 0000-0002-9273-0574Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jesse E. HansoniD· 3 shared Hai NguiD· 2 shared Luke XieiD· 2 shared Ming‐Chi TsaiiD· 2 shared Oded ForemaniD· 2 shared Shristi PandeyiD· 2 shared Alexander MunkiD· 1 shared Alvin GogineniiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Jesse E. HansonORCID

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3 papers

Recent·Most cited

Complement C3aR deletion does not attenuate neurodegeneration in a tauopathy model or alter acute inflammation-induced gene expression changes in the brain

Yuanyuan Wang, Shristi Pandey, Martin Weber, Man Kin Choy, Tiffany Z. Wu, Tania Chernov-Rogan, Hai Ngu, Oded Foreman, Luke Xie, Jesse E. Hanson

This study shows that deleting C3aR does not reduce neurodegeneration in a tauopathy model or alter gene expression changes during acute inflammation.

bioRxiv · Jun 16, 2025 · PreprintNeuroscience

Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer's disease

Yuanyuan Wang, Tiffany Z. Wu, Alvin Gogineni, Ming‐Chi Tsai, Lukasz Jan Kielpinski, Anubha Mahajan, Shristi Pandey, Luis F. Schachner, John C. Tran, Cong Wu, Stephen P. Schauer, Anne Biever, Sidsel Boesen, Meiling Li, Alexander Munk, , Jesse E. Hanson

This study identifies the classical complement pathway as a therapeutic target in Alzheimer's disease and demonstrates the efficacy of antisense oligonucleotides in rescuing synapse loss in mouse models.

bioRxiv · Aug 23, 2024 · PreprintNeuroscience

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

Yuanyuan Wang, Tiffany Z. Wu, Ming‐Chi Tsai, Mitchell G. Rezzonico, Alyaa M. Abdel‐Haleem, Luke Xie, Vineela D. Gandham, Hai Ngu, Kimberly L. Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A. Friedman, Morgan Sheng, Jesse E. Hanson

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.

eLife · Jul 31, 2023Peer-reviewedNeuroscience