Author

Lukasz Jan Kielpinski

F. Hoffmann-La Roche AGORCID 0000-0001-5000-5561Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander MunkiD· 1 shared Alvin GogineniiD· 1 shared Amy E. EastoniD· 1 shared Anne BieveriD· 1 shared Anubha MahajaniD· 1 shared Cong WuiD· 1 shared Erich KolleriD· 1 shared Helene M. GyllingiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alexander MunkORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedOct 9, 2026

Antisense oligonucleotides targeting transcription termination windows disrupt mRNA 3' end processing and decrease gene expression

Kinga Winczura, Lars Joenson, Erich Koller…·Lukasz Jan Kielpinski

This study shows that antisense oligonucleotides targeting transcription termination windows can decrease gene expression by disrupting mRNA 3' end processing and causing off-target effects.

2 citationstop 5%

multiomeexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 23, 2024

Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer's disease

Yuanyuan Wang, Tiffany Z. Wu, Alvin Gogineni…·Jesse E. Hanson

This study identifies the classical complement pathway as a therapeutic target in Alzheimer's disease and demonstrates the efficacy of antisense oligonucleotides in rescuing synapse loss in mouse models.

4 citations

humanproteomics

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