Ming‐Chi Tsai

This paper introduces a method to degrade proteins using small tags and an artificial bacterial E3 ligase, demonstrating its effectiveness in neurons and mouse brains.

This study identifies the classical complement pathway as a therapeutic target in Alzheimer's disease and demonstrates the efficacy of antisense oligonucleotides in rescuing synapse loss in mouse models.

The paper develops a CRISPRi-based screening platform to identify genes affecting neuronal excitability in human iPSC-derived neurons, revealing new links to neurodegenerative and neurodevelopmental disorders.

This study identifies Tmc3-expressing vagal ganglion neurons that regulate broncho-constriction and dilation, impacting respiratory function and offering potential therapeutic targets for respiratory diseases.

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.