This study identifies integrin α5β1 as the receptor for vasoinhibin's HGR motif, revealing its role in inhibiting angiogenesis and vascular permeability through integrin activation.

Journal of Biological Chemistry · Nov 26, 2025Peer-reviewedCell Biology

Topical Ophthalmic Administration of VIAN-c4551 Antiangiogenic Peptide for Diabetic Macular Edema: Preclinical Efficacy and Ocular Pharmacokinetics

Elva Adán‐Castro, Magdalena Zamora, Daniela Granados-Carrasco, Lourdes Siqueiros‐Márquez, José Fernando García-Rodrigo, Fernando Macías, Thomas Bertsch, Jakob Triebel, Edith Arnold, Gonzalo Martı́nez de la Escalera, Juan Pablo Robles, Carmen Clapp

This study evaluates VIAN-c4551 eye drops for treating diabetic macular edema, showing they reach therapeutic concentrations in the retina and reduce vascular leakage.

Scientific Reports · Jul 23, 2025Peer-reviewedPharmacology & Toxicology

The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability

Alma Lorena Perez, Magdalena Zamora, Manuel M. Bahena, Regina M. Aramburo-Williams, Elva Adán‐Castro, Daniela Granados-Carrasco, Thomas Bertsch, Jakob Triebel, Gonzalo Martı́nez de la Escalera, Juan Pablo Robles, Carmen Clapp

This study shows that VIAN-c4551 reduces lung melanoma metastasis in mice by inhibiting vascular permeability and melanoma cell extravasation.

PLoS ONE · May 28, 2025Peer-reviewedCancer Biology

Vasoinhibin is Generated by the Renin-Angiotensin System

Francisco Freinet Núñez, Lourdes Siqueiros‐Márquez, Elva Adán‐Castro, Magdalena Zamora, Juan Pablo Robles, Xarubet Ruíz‐Herrera, Thomas Bertsch, Jakob Triebel, Gonzalo Martı́nez de la Escalera, Carmen Clapp

This study identifies renin as a protease that cleaves prolactin to generate vasoinhibin, a RAS-mediated regulator of blood vessel growth and function.

Endocrinology · Jan 31, 2025Peer-reviewedPhysiology