Systems BiologybioRxivPreprint
Quantitative Modeling of TLR Signaling Reveals Missing Negative Feedback Guiding Identification of TANK-IKKε Checkpoint
Nathan P. Manes, Fengkai Zhang, Bin Lin…·Aleksandra Nita‐Lazar
The paper develops a rule-based model of TLR4 signaling in mouse macrophages, identifies a missing negative feedback checkpoint involving TANK and IKKε, and validates its role in restraining inflammation.
DOI 10.64898/2026.08.03.742528