Aleksandra Nita‐Lazar

The paper develops a rule-based model of TLR4 signaling in mouse macrophages, identifies a missing negative feedback checkpoint involving TANK and IKKε, and validates its role in restraining inflammation.

This study shows that sulfide is essential for gut microbial and immune homeostasis, with its depletion causing immune dysfunction and impaired vaccine response.

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

The paper shows macrophages use TLR4 memory and IL-10 susceptibility gating to adjust inflammation based on pathogen dynamics.