Author

Leonard Spranger

Charité – Universitätsmedizin BerlinORCID 0000-0002-4316-2961Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Organism:yeast· 1

Frequent Co-Authors

Aleksej ZelezniakiD· 1 shared Antonis RokasiD· 1 shared Ben D ColemaniD· 1 shared Benjamin Murray HeineikeiD· 1 shared Chris MungalliD· 1 shared Cory Thomas Lee· 1 shared Elena CasiraghiiD· 1 shared Federica AgostiniiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Aleksej ZelezniakORCID

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2 papers

Recent·Most cited

Systems BiologyNaturePeer-reviewedJul 9, 2025

The Role of Metabolism in Shaping Enzyme Structures Over 400 Million Years of Evolution

Oliver Lemke, Benjamin Murray Heineike, Sandra Viknander…·Markus Ralser

This study uses AlphaFold2 to analyze how metabolism influenced enzyme structural evolution across 400 million years by examining 11,269 enzyme structures and their metabolic reactions.

28 citationstop 1%

yeastprotein structure

𝕏 PostBluesky

BioinformaticsbioRxivPreprintNov 21, 2022

Node-degree aware edge sampling mitigates inflated classification performance in biomedical graph representation learning

Luca Cappelletti, Lauren Rekerle, Tommaso Fontana…·Peter N. Robinson

The paper introduces a degree-aware edge sampling method to reduce performance inflation in biomedical graph representation learning caused by imbalanced edge degree distributions.

1 citation

statistical modelbenchmarking

𝕏 PostBluesky