Federica Agostini

The Role of Metabolism in Shaping Enzyme Structures Over 400 Million Years of Evolution

This study uses AlphaFold2 to analyze how metabolism influenced enzyme structural evolution across 400 million years by examining 11,269 enzyme structures and their metabolic reactions.

The natural diversity of the yeast proteome reveals chromosome-wide dosage compensation in aneuploids

The paper quantifies proteomic effects of aneuploidy in natural yeast isolates, finding chromosome-wide dosage compensation in the proteome but not transcriptome.

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy

The paper shows yeast cells can cooperatively compensate for methionine auxotrophy by using a new homocysteine synthase, HSU1, to re-assimilate hydrogen sulfide.

Laboratory evolution of Escherichia coli enables life based on fluorinated amino acids

This study shows that Escherichia coli can adapt to use fluorinated indoles as essential precursors for protein synthesis through few genetic mutations and significant regulatory and cellular changes.