Pharmacology & ToxicologyBiochemical PharmacologyPeer-reviewed
A novel pipeline for the validation of manganese chelators for the treatment of manganese overload
Hendrik Vogt, Chiara Pojani, Jack Devonport…·Karin Tuschl
This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.