Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer
Lisanne Mout, Thaidy Moreno-Rodriguez, Giacomo Grillo, Ankita Nand, Tina Keshavarzian, Shalini Bahl, Komaldeep Kang, Matthew L. Bootsma, Emma Minnee, Stanley Zhou, Kathleen H. Burns, Eva Corey, Peter S. Nelson, Scott M. Dehm, Shuang George Zhao, , Mathieu Lupien
The paper identifies a subgroup of mCRPC characterized by LINE1 repeat DNA elements flanking the AR gene, which drive AR overexpression and confer resistance to androgen signaling inhibitors.
bioRxiv · Aug 8, 2025 · PreprintCancer Biology