Author

Giacomo Grillo

University Health NetworkORCID 0000-0003-4832-0954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Mathieu LupieniD· 2 shared Alexander J. Murison· 1 shared Alexandra N. Fedor· 1 shared Alice JouneauiD· 1 shared Ankita NandiD· 1 shared Benjamin Haibe‐KainsiD· 1 shared C.H. ArrowsmithiD· 1 shared Claire FrancasteliD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Mathieu LupienORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 8, 2025

Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer

Lisanne Mout, Thaidy Moreno-Rodriguez, Giacomo Grillo…·Mathieu Lupien

The paper identifies a subgroup of mCRPC characterized by LINE1 repeat DNA elements flanking the AR gene, which drive AR overexpression and confer resistance to androgen signaling inhibitors.

4 citations

humanHi-C

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GenomicsHuman Molecular GeneticsPeer-reviewedNov 7, 2024

ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats

Giacomo Grillo, Ekaterina Boyarchuk, Seed Mihic…·Claire Francastel

This study identifies ZBTB24 as a transcription factor that regulates DNA methylation and expression of centromeric satellite repeats in human and mouse cells.

4 citations

humanmouse

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GenomicsbioRxivPreprintMar 28, 2018

Metabolic adaptations underlie epigenetic vulnerabilities in chemoresistant breast cancer.

Geneviève Deblois, Seyed Ali Madani Tonekaboni, Yunchi Ingrid Kao…·Mathieu Lupien

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.

4 citations

humanDNA methylation

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