Shuang George Zhao

Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer

The paper identifies a subgroup of mCRPC characterized by LINE1 repeat DNA elements flanking the AR gene, which drive AR overexpression and confer resistance to androgen signaling inhibitors.

OGDHL regulates tumor growth, neuroendocrine marker expression, and nucleotide abundance in prostate cancer

This study identifies OGDHL as a regulator of tumor growth, neuroendocrine marker expression, and nucleotide abundance in prostate cancer, with implications for treatment resistance.

Development of FAP-targeted theranostics discovered by next-generation sequencing-augmented mining of a novel immunized VNAR library

The paper develops FAP-targeted theranostics using VNARs from a shark antibody library, showing high affinity and efficacy in vitro and in vivo.

A prostate cancer gastrointestinal transcriptional phenotype may be associated with diminished response to AR-targeted therapy

This study identifies a gastrointestinal gene expression phenotype in metastatic castration-resistant prostate cancer that correlates with reduced response to androgen receptor inhibitors.

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

This study shows that purine metabolism affects DNA repair and therapy resistance in glioblastoma, suggesting that targeting purine synthesis could improve treatment outcomes.