Grant N. Wheeler

MicroRNA miR-219 is required for neural border and neural crest development in Xenopus neurulas

This study identifies miR-219 as a regulator of neural crest development in Xenopus by showing its role in neural border specification and gene expression modulation.

MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos.

This study identifies miR-196a as a regulator of neural crest development in Xenopus embryos by repressing immature neural ectoderm programs and promoting neural crest and neuron differentiation.

Genomic analyses reveal FoxG as an upstream regulator of wnt1 required for posterior identity specification in planarians

The paper identifies FoxG as an upstream regulator of wnt1 involved in posterior identity specification during planarian regeneration through genomic analyses.

An efficient miRNA knockout approach using CRISPR-Cas9 in Xenopus

The paper develops a CRISPR-Cas9 approach to knockout miRNAs in Xenopus and shows that miR-196a and miR-219 knockouts result in neural crest defects similar to morpholino knockdowns.

Characterising open chromatin identifies novel cis-regulatory elements important for paraxial mesoderm formation and axis extension

The paper identifies novel cis-regulatory elements involved in paraxial mesoderm formation and axis extension using chromatin accessibility and transcriptomic data from chick embryos.

FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord

This study identifies FZD10 as a receptor for Wnt1 in spinal cord development, showing it regulates neurogenesis and proliferation, but requires Lrp6 for full activity.