Matthew Guille

This study identifies Mena as a key mediator of Wnt signalosome endocytosis, showing it promotes Wnt signaling by binding LRP5/6 and facilitating receptor uptake.

The paper introduces Cleland immunoblotting, a method to detect cysteine redox proteoforms by reversing PEG-payload mobility shifts, revealing previously undetectable proteoforms in Xenopus oocytes.

The paper identifies de novo monoallelic DDX17 variants in 11 patients with neurodevelopmental disorders and shows DDX17 dysfunction causes neuronal migration and axon outgrowth defects in multiple models.

The paper develops a CRISPR-Cas9 approach to knockout miRNAs in Xenopus and shows that miR-196a and miR-219 knockouts result in neural crest defects similar to morpholino knockdowns.