Eirini Maniou

This study shows that local anisotropic stress and cytoskeletal organization, rather than actomyosin purse-string contraction, drive cell shape and motion during hindbrain neuropore closure in mouse embryos.

The paper shows that sparse mesenchymal networks behave like a fluid under tension, driven by contact inhibition of locomotion, and identifies this as a new tissue behavior with implications for development and tumorigenesis.

This study examines spinal neural tube formation and tail development in human embryos, finding patterns similar to mouse and rat, including primary neurulation completion and secondary neurulation characteristics.

This study identifies CFL1-dependent cell behaviours driving spinal zippering in mice and shows that its deletion impairs zippering and causes spina bifida.

This study shows that disrupting Fgfr1 in mice causes localized spinal mis-patterning and a terminal myelocystocele-like phenotype after neural tube closure.

The paper shows that the geometry of the hindbrain neuropore in mouse embryos determines asymmetric closure dynamics through cell-mediated mechanisms.

The paper identifies novel cis-regulatory elements involved in paraxial mesoderm formation and axis extension using chromatin accessibility and transcriptomic data from chick embryos.