RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells in DMD
Esther Fernández‐Simón, Xavier Suárez‐Calvet, Ana Carrasco‐Rozas, Patricia Piñol‐Jurado, Susana López Fernández, Gemma Pons, Joan Josep Bech‐Serra, Carolina de la Torre, Noemí de Luna, Eduard Gallardo, Jordi Díaz‐Manera
This study shows PDGF-AA activates the RhoA/ROCK2 pathway in DMD fibro-adipogenic progenitor cells, leading to fibrosis, and that blocking this pathway improves muscle function in a mouse model.
Journal of Cachexia Sarcopenia and Muscle · Feb 7, 2022Peer-reviewedMolecular Biology