Kesavan Meganathan

Autism and Intellectual Disability-Associated MYT1L Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and Physiology

This study examines how pathogenic MYT1L mutations affect human cortical interneuron differentiation, maturation, and physiology using stem cell models.

Alterations in neuronal physiology, development, and function associated with a common duplication of chromosome 15 involving CHRNA7

This study uses iPSC models to show that a 15q13.3 duplication causes distinct neurodevelopmental and functional anomalies in an affected individual but not their unaffected mother, while both share increased cholinergic activity.

Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons

This study models multiplex autism using iPSC-derived neurons from a family with varying ASD liability, identifying morphological, physiological, and transcriptomic changes linked to polygenic susceptibility.