Emily M. Adams

A cornea-specific role for the Aspergillus fumigatus carbon catabolite repressor, CreA, in tissue penetration and infection establishment

This study shows that the Aspergillus fumigatus CreA repressor is critical for corneal infection by enabling hyphal invasion, while gluconeogenesis is not required for infection in lung or cornea.

The mammalian Ire1 inhibitor, 4μ8C, exhibits broad anti-Aspergillus activity in vitro and in a treatment model of fungal keratitis.

This paper investigates the antifungal properties of 4μ8C, an Ire1 inhibitor, showing strong activity against Aspergillus fumigatus in vitro and in a fungal keratitis treatment model.