Can Zhao

Live 4D monitoring of fungal infection in an ex vivo model of fungal keratitis reveals enhanced efficacy of combined PACK-CXL and natamycin treatment

This study develops an ex vivo porcine corneal model to evaluate combined natamycin and PACK-CXL treatment for fungal keratitis, showing it reduces fungal burden more effectively than either treatment alone.

A cornea-specific role for the Aspergillus fumigatus carbon catabolite repressor, CreA, in tissue penetration and infection establishment

This study shows that the Aspergillus fumigatus CreA repressor is critical for corneal infection by enabling hyphal invasion, while gluconeogenesis is not required for infection in lung or cornea.

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

The paper identifies genes involved in sulfur metabolism in Aspergillus fumigatus during infection, highlighting ShmB as a promising antifungal target due to its essential role in virulence and structural differences from the human enzyme.