Template switching during DNA replication is a prevalent source of adaptive gene amplification
Julie N. Chuong, Nadav Ben Nun, Ina Suresh, Julia Cano Matthews, Titir De, Grace Avecilla, Farah Abdul‐Rahman, Nathan Brandt, Yoav Ram, David Gresham
The paper investigates how genomic architecture influences the formation and fitness of adaptive copy number variants (CNVs) in yeast, finding that template switching during DNA replication is a common mechanism for CNV generation.
eLife · Aug 2, 2024Peer-reviewedEvolutionary Biology