Ina Suresh

This study shows that high spontaneous aneuploidy rates, not drug-induced mutations, drive fluconazole resistance in yeast through chromosome duplication at ERG11.

This study shows segmental copy number amplifications are more stable than aneuploidies when selection pressure is removed, with aneuploidies reverting quickly and losing fitness.

The paper investigates how genomic architecture influences the formation and fitness of adaptive copy number variants (CNVs) in yeast, finding that template switching during DNA replication is a common mechanism for CNV generation.

This paper develops a deep learning model to estimate gene regulatory networks and RNA kinetics from single-cell RNA-seq data, showing improved recovery of known regulatory relationships and predictive power.