Grace Avecilla

This study shows segmental copy number amplifications are more stable than aneuploidies when selection pressure is removed, with aneuploidies reverting quickly and losing fitness.

The paper investigates how genomic architecture influences the formation and fitness of adaptive copy number variants (CNVs) in yeast, finding that template switching during DNA replication is a common mechanism for CNV generation.

The paper investigates how copy number variants (CNVs) in yeast affect mutational tolerance and fitness, finding both increased tolerance in translation-related genes and decreased tolerance in mitochondrial function genes.