Colleen E Hannon

Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors

The paper tests whether intrinsic protein disorder drives subnuclear clustering of transcription factors in Drosophila embryos and finds that IDRs alone are insufficient for this clustering.

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

This study shows that transcription factors like Zelda and Bicoid form dynamic, transient hubs in Drosophila embryos that interact with active transcription sites.

Concentration Dependent Chromatin States Induced by the Bicoid Morphogen Gradient

The paper shows that Bicoid's occupancy at target sites depends on chromatin context rather than binding sites, with Bcd inducing an open chromatin state at high concentrations.