Shelby A. Blythe

The paper develops a reaction-diffusion framework to model Polycomb spreading during embryogenesis and shows PRC2 diffusion is enhanced by PRC1.

The paper investigates how Polycomb modifications spread during Drosophila zygotic genome activation, showing nucleation-dependent propagation and the role of Zelda in licensing PREs.

The paper shows that cells interpret dynamic morphogen signals through temporal integration and spatial competence, using Drosophila BMP gradients to demonstrate this mechanism.

The paper shows that Bicoid-nucleosome competition sets a concentration threshold for hunchback transcription, constrained by genome replication in Drosophila embryos.

The paper develops a mathematical model to investigate how allostery and nucleation contribute to H3K27 methylation dynamics in early Drosophila embryogenesis.

The paper examines the anterior-posterior symmetry-breaking mechanism in Clogmia albipunctata, showing that its AD, maternal Cal-opa, promotes chromatin accessibility and anterior gene expression, similar to Drosophila's Bcd mechanism.

This study shows that the pioneer factor GAF localizes to subnuclear foci through binding to GA-satellite repeats, which is necessary for forming heterochromatin and silencing satellite repeat expression.

The paper develops a two-stage marker-assisted pipeline using sgRNA-Cas9 RNPs to improve genome editing efficiency in Drosophila by enabling precise HDR and screening based on eye morphology.

The paper shows that Odd-paired/Zic pioneer factor activity is essential for establishing the Drosophila segmentation network by regulating chromatin accessibility.

The paper investigates how chromatin accessibility and histone acetylation regulate the loss of competence to inductive signals during early development in Xenopus laevis.

The paper shows that Bicoid's occupancy at target sites depends on chromatin context rather than binding sites, with Bcd inducing an open chromatin state at high concentrations.