Mustafa Mir

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

The paper uses live-imaging and computational modeling to show that Dorsal hub formation in Drosophila embryos depends on TF-DNA binding kinetics, not enhancer sequence or higher-order regulatory structures.

The paper develops a computational model to show that molecular diffusion and binding kinetics can explain nuclear protein clustering without requiring phase separation or protein-protein interactions.

This study shows that enhancer-promoter configurations in Drosophila embryos affect transcriptional dynamics, with downstream enhancer positioning reducing mRNA output by 70%.

The paper investigates RNAPII clustering during ZGA in Drosophila embryos, showing clusters are stably associated with active genes and reflect transcriptional activity, not phase separation.

The paper investigates how transcription factor hubs are localized to target genes through a kinetic balance of interactions in Drosophila embryos.

This study shows that the pioneer factor GAF localizes to subnuclear foci through binding to GA-satellite repeats, which is necessary for forming heterochromatin and silencing satellite repeat expression.

This study shows that transcription factors like Zelda and Bicoid form dynamic, transient hubs in Drosophila embryos that interact with active transcription sites.

The paper uses live imaging in Drosophila embryos to show that Bicoid binds DNA with a rapid off-rate and forms localized hubs that enable concentration-sensitive regulation.