Bo Liu

gcSV is a structural variant detection framework that improves accuracy and yield across long, hybrid, and short-read data, identifying over 93,000 novel SVs.

xRead improves scalability and efficiency for constructing read overlapping graphs in long-read sequencing by using a coverage-guided model and heuristic alignment skeleton approach.

abPOA is a fast partial order alignment library using SIMD acceleration, achieving 15x speed improvement over SPOA with similar accuracy.

cuteSV improves structural variation detection in long-read sequencing by combining signature-based methods with clustering and refinement, achieving better performance on real datasets.

deSALT improves long RNA-seq read alignment by addressing sequencing errors and gene structure complexity through a two-pass graph-based approach.

deGSM constructs large de Bruijn graphs efficiently in limited memory, handling terabase-pair datasets on standard hardware.