NeuroscienceActa NeuropathologicaPeer-reviewed
Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies
Silas A. Buck, Tuyana B. Malankhanova, Samuel Strader…·Laurie H. Sanders
This study shows that LRRK2-mediated phosphorylation of Rab12 accumulates in lysosomal-like structures in tauopathies and synucleinopathies, linking LRRK2 kinase activity to endolysosomal dysfunction.
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