Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies
Silas A. Buck, Tuyana B. Malankhanova, Samuel Strader, B. Eileen, Sarah Yim, Harrison W Pratt, John F. Ervin, Edward B. Lee, Shih‐Hsiu J. Wang, Todd J. Cohen, Andrew B. West, Laurie H. Sanders
This study shows that LRRK2-mediated phosphorylation of Rab12 accumulates in lysosomal-like structures in tauopathies and synucleinopathies, linking LRRK2 kinase activity to endolysosomal dysfunction.
Acta Neuropathologica · Oct 23, 2025Peer-reviewedNeuroscience