Samuel Strader

This study identifies lysosomal swelling as a trigger for LRRK2-mediated Rab phosphorylation, independent of membrane damage or PIKfyve inhibition.

This study shows that LRRK2-mediated phosphorylation of Rab12 accumulates in lysosomal-like structures in tauopathies and synucleinopathies, linking LRRK2 kinase activity to endolysosomal dysfunction.

This study reports the atomic structure of mouse α-synuclein fibrils and shows they differ structurally and functionally from human fibrils linked to Parkinson's and MSA.

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

This study shows that Thrombospondin-1 promotes circuit-specific synapse formation in direction-selective retinal ganglion cells via β1-integrin.