Shih‐Hsiu J. Wang

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer's Disease (AD)

This study uses multi-region spatial transcriptomics to identify region-specific transcriptional responses to Aβ plaques in AD, revealing differences in neuronal vulnerability and molecular pathways.

Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies

This study shows that LRRK2-mediated phosphorylation of Rab12 accumulates in lysosomal-like structures in tauopathies and synucleinopathies, linking LRRK2 kinase activity to endolysosomal dysfunction.

Lipid Mediated Formation of Antiparallel Aggregates in Cerebral Amyloid Angiopathy

This study investigates the structural characteristics of amyloid-beta aggregates in cerebral amyloid angiopathy, identifying antiparallel beta-sheet structures linked to lipid-mediated aggregation.

Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donors

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.