Author
University of PittsburghORCID 0000-0002-9476-9210Unclaimed ORCID profile · follow to get notified of new preprints
10 papers
Recent·Most cited
Tara Richbourg, Alex George, Anas Bitar, Ian T. Ryde, Casey Farrell, Tuyana B. Malankhanova, Jennifer Liu, Silas A. Buck, Ivana Barraza, So Young A Kim, Xiaoyan Nie, Andrew B. West, Joel N. Meyer, Laurie H. Sanders
This study identifies Rab12 as a negative regulator of mitophagy and mitochondrial homeostasis, showing its loss increases mitochondrial clearance and sensitivity to stress.
bioRxiv · Mar 31, 2026 · PreprintCell Biology
Courtney J. Wright, Silas A. Buck, Snezana Milosavljevic, Ashley M. Lewis, Nathan T. J. Wagner, Ana Pocivavsek
This study investigates how time of day affects kynurenic acid (KYNA) synthesis and inhibition in rats, showing phase-dependent changes in KYNA levels and KAT II enzyme activity.
ACS Chemical Neuroscience · Mar 27, 2026Peer-reviewedNeuroscience
Silas A. Buck, Tuyana B. Malankhanova, Samuel Strader, B. Eileen, Sarah Yim, Harrison W Pratt, John F. Ervin, Edward B. Lee, Shih‐Hsiu J. Wang, Todd J. Cohen, Andrew B. West, Laurie H. Sanders
This study shows that LRRK2-mediated phosphorylation of Rab12 accumulates in lysosomal-like structures in tauopathies and synucleinopathies, linking LRRK2 kinase activity to endolysosomal dysfunction.
Acta Neuropathologica · Oct 23, 2025Peer-reviewedNeuroscience
Mostofa Rafid Uddin, Zhiqian Zheng, Kashish Gandhi, Hung‐Ching Chang, Jenesis Kozel, Yaswanth Gali, Silas A. Buck, Jill R. Glausier, George C. Tseng, Zachary Freyberg, Min Xu
The paper develops a computational pipeline to link nuclear morphology to mRNA expression in neurons across aging in mice and humans, revealing subtype-specific morphology differences and age-related interactions.
bioRxiv · Oct 16, 2025 · PreprintBioinformatics
Jiying Ning, Jill R. Glausier, Rangana Warshamanage, Leslie Gunther-Cummins, B. Tom Burnley, Colin M. Palmer, Guillermo González‐Burgos, Takeaki Miyamae, Jing Wang, Diane L. Carlisle, Chyongere Hsieh, Thomas Schmelzer, Silas A. Buck, Jonathan M. Franks, Cheri M. Hampton, , Zachary Freyberg
This paper introduces SISTM to map 3D synaptic nanoarchitecture in brain tissue across species using cryo-ET and STA, revealing conserved structural features in human postmortem tissue.
bioRxiv · Mar 9, 2025 · PreprintCell Biology
Silas A. Buck, Samuel J. Mabry, Jill R. Glausier, Tabitha Banks‐Tibbs, Caroline Ward, Jenesis Kozel, Chen Fu, Kenneth N. Fish, David A. Lewis, Ryan Wellington Logan, Zachary Freyberg
The paper shows aging reduces mRNA expression of dopamine and glutamate markers in midbrain neurons of mice and humans, but not protein levels or cell numbers.
Molecular Psychiatry · Jan 28, 2025Peer-reviewedNeuroscience
Silas A. Buck, Sophie A. Rubin, Tenzin Kunkhyen, Christoph D. Treiber, Xiangning Xue, Lief E. Fenno, Samuel J. Mabry, Varun R. Sundar, Zilu Yang, Divia Shah, Kyle D. Ketchesin, Darius D. Becker‐Krail, Iaroslavna Vasylieva, Megan C. Smith, Florian J. Weisel, , Zachary Freyberg
This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.
bioRxiv · Oct 2, 2023 · PreprintNeuroscience
Jenesis D. Gayden, Stéphanie Puig, Chaitanya Srinivasan, BaDoi N. Phan, Ghada Abdelhady, Silas A. Buck, Mackenzie C. Gamble, Hugo A. Tejeda, Yan Dong, Andreas R. Pfenning, Ryan Wellington Logan, Zachary Freyberg
The paper characterizes striatal projection neuron heterogeneity in mice using single-nuclei multi-omics and spatial mapping, revealing distinct subtypes with unique receptor expression and disease risk contributions.
bioRxiv · May 4, 2023 · PreprintNeuroscience
Jiying Ning, Jill R. Glausier, Chyongere Hsieh, Thomas Schmelzer, Silas A. Buck, Jonathan M. Franks, Cheri M. Hampton, David A. Lewis, Michael Marko, Zachary Freyberg
The paper introduces a cryo-FIB workflow to image brain tissue via in situ cryo-EM, enabling visualization of subcellular structures in fresh, unfixed mouse and postmortem human brain tissue.
bioRxiv · Feb 11, 2023 · PreprintNeuroscience
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma I. O’Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan Wellington Logan, Jill R. Glausier, Kenneth N. Fish, , Zachary Freyberg
The paper identifies VGLUT expression as a sex-dependent mediator of age-related dopamine neuron vulnerability in Parkinson's disease.
Aging Cell · Apr 28, 2021Peer-reviewedNeuroscience