Lawrence K. Lee

Passivating blunt-ended helices to control monodispersity and multi-subunit assembly of DNA origami structures

This study evaluates methods to prevent aggregation and control multi-subunit assembly in DNA origami by comparing scaffold loops, poly-nucleotide brushes, and orthogonal DNA helices.

Rapid exchange of stably bound protein and DNA cargo on a DNA origami receptor

This paper designs a DNA origami receptor that enables stable complexes with rapid subunit exchange, demonstrating the system's ability to handle both DNA and protein cargo.

Design and Synthesis of Pleated DNA Origami Nanotubes with Adjustable Diameters

The paper designs and synthesizes pleated DNA origami nanotubes with adjustable diameters using a computational method for determining staple crossover locations.