Antoine M. van Oijen

This study uses single-molecule techniques to show how Hsp90 helps Hsp70 release folding intermediates and remodel client proteins to enable proper refolding.

This study uses smFRET to visualize how Hsp70 remodels misfolded Fluc under chemical and heat stress, revealing conformational expansion and Hsp110-driven release for productive folding.

This study investigates how DNA supercoiling affects the activity of the restriction enzyme EcoRV at the single-molecule level using TIRF microscopy.

This study investigates the interaction between sHsps and Hsp70 chaperones in α-synuclein disaggregation and aggregation, finding no synergy and potential antagonism between the chaperone classes.

This paper introduces a DNA barcoding method to simultaneously profile kinetic properties of protein variants at the single-molecule level, revealing kinetic diversity and structural subpopulations.

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

This study uses single-molecule techniques to characterize how human sHsps bind to aggregation-prone client proteins and form complexes.

This study investigates how designer PPR proteins bind to specific RNA sequences, showing they do not scan longer RNAs and instead rely on diffusion, with implications for their localization in organelles.

This paper designs a DNA origami receptor that enables stable complexes with rapid subunit exchange, demonstrating the system's ability to handle both DNA and protein cargo.

The paper shows ROS-induced DNA double-strand breaks enhance DNA polymerase IV activity in E. coli through SOS-mediated concentration increases and direct repair roles.